Endogenous aFGF expression and cellular changes after a demyelinating lesion in the spinal cord of adult normal mice: Immunohistochemical study
Identifieur interne : 000069 ( France/Analysis ); précédent : 000068; suivant : 000070Endogenous aFGF expression and cellular changes after a demyelinating lesion in the spinal cord of adult normal mice: Immunohistochemical study
Auteurs : A. Tourbah [France] ; A. Baron-Van Evercooren [France] ; L. Oliver [France] ; D. Raulais [France] ; J. C. Jeanny [France] ; M. Gumpel [France]Source :
- Journal of Neuroscience Research [ 0360-4012 ] ; 1992-09.
English descriptors
- Teeft :
- Acidic, Acidic fibroblast growth factor, Afgf, Afgf expression, Afgf immunostaining, Afgf localization, Astrocyte, Basic fibroblast growth factor, Basic fibroblast growth factors, Bovine brain, Cell density, Cell type, Cellular, Cellular changes, Contralateral, Contralateral side, Demyelinated, Demyelinated area, Demyelinated lesion, Demyelinating, Demyelinating lesion, Demyelination, Extracellular, Extracellular staining, Fgfs, Fibroblast, Fibroblast growth factor, Gfap, Glial, Glial cells, Growth factor, Immunohistochemical, Immunohistochemical study, Immunostaining, Inserm, Lesion, Localization, Macrophage, Mckinnon, Microglial, Microglial cells, Myelin, Myelinated area, Neuron, Neuronal, Neurosci, Normal mice, Odcs, Present study, Proc natl acad, Progenitor, Progenitor cells, Raff, Remyelinating process, Remyelination, Spinal, Spinal cord, Swine antibody, Tourbah, Triple staining, Vellis.
Abstract
Fibroblast growth factors (FGFs) are known to act on glial cells in vitro. At the present time, their involvement in the remyelinating process of the adult central nervous system (CNS) is still unknown. In the present study, using immunohistochemistry (IHC), we investigated the evolution in time and space of acidic FGF (aFGF) expression and CNS cell changes occurring after a chemically induced demyelinating lesion. In a first early period, aFGF immunostaining was shown to decrease around the demyelinated area. A dramatic increase was then observed and was accompanied by an increase of cell density around and inside the lesion. This was correlated with the beginning of remyelination. Late after demyelination, while remyelination was still in progress, aFGF immunostaining of the lesion and unlesioned spinal cord were comparable. A role of aFGF in remyelination is proposed. © 1992 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jnr.490330107
Affiliations:
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ISTEX:E323502EB4ECC22D778D544CD8008B7D4AC91BC1Le document en format XML
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Raulais</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM U. 118, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Jeanny, J C" sort="Jeanny, J C" uniqKey="Jeanny J" first="J. C." last="Jeanny">J. C. Jeanny</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM U. 118, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Gumpel, M" sort="Gumpel, M" uniqKey="Gumpel M" first="M." last="Gumpel">M. Gumpel</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM U. 134, Hôpital de la Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Neuroscience Research</title><title level="j" type="alt">JOURNAL OF NEUROSCIENCE RESEARCH</title><idno type="ISSN">0360-4012</idno><idno type="eISSN">1097-4547</idno><imprint><biblScope unit="vol">33</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="47">47</biblScope><biblScope unit="page" to="59">59</biblScope><biblScope unit="page-count">13</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1992-09">1992-09</date></imprint><idno type="ISSN">0360-4012</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0360-4012</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acidic</term><term>Acidic fibroblast growth factor</term><term>Afgf</term><term>Afgf expression</term><term>Afgf immunostaining</term><term>Afgf localization</term><term>Astrocyte</term><term>Basic fibroblast growth factor</term><term>Basic fibroblast growth factors</term><term>Bovine brain</term><term>Cell density</term><term>Cell type</term><term>Cellular</term><term>Cellular changes</term><term>Contralateral</term><term>Contralateral side</term><term>Demyelinated</term><term>Demyelinated area</term><term>Demyelinated lesion</term><term>Demyelinating</term><term>Demyelinating lesion</term><term>Demyelination</term><term>Extracellular</term><term>Extracellular staining</term><term>Fgfs</term><term>Fibroblast</term><term>Fibroblast growth factor</term><term>Gfap</term><term>Glial</term><term>Glial cells</term><term>Growth factor</term><term>Immunohistochemical</term><term>Immunohistochemical study</term><term>Immunostaining</term><term>Inserm</term><term>Lesion</term><term>Localization</term><term>Macrophage</term><term>Mckinnon</term><term>Microglial</term><term>Microglial cells</term><term>Myelin</term><term>Myelinated area</term><term>Neuron</term><term>Neuronal</term><term>Neurosci</term><term>Normal mice</term><term>Odcs</term><term>Present study</term><term>Proc natl acad</term><term>Progenitor</term><term>Progenitor cells</term><term>Raff</term><term>Remyelinating process</term><term>Remyelination</term><term>Spinal</term><term>Spinal cord</term><term>Swine antibody</term><term>Tourbah</term><term>Triple staining</term><term>Vellis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Fibroblast growth factors (FGFs) are known to act on glial cells in vitro. At the present time, their involvement in the remyelinating process of the adult central nervous system (CNS) is still unknown. In the present study, using immunohistochemistry (IHC), we investigated the evolution in time and space of acidic FGF (aFGF) expression and CNS cell changes occurring after a chemically induced demyelinating lesion. In a first early period, aFGF immunostaining was shown to decrease around the demyelinated area. A dramatic increase was then observed and was accompanied by an increase of cell density around and inside the lesion. This was correlated with the beginning of remyelination. Late after demyelination, while remyelination was still in progress, aFGF immunostaining of the lesion and unlesioned spinal cord were comparable. A role of aFGF in remyelination is proposed. © 1992 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Tourbah, A" sort="Tourbah, A" uniqKey="Tourbah A" first="A." last="Tourbah">A. Tourbah</name></region><name sortKey="Baron An Evercooren, A" sort="Baron An Evercooren, A" uniqKey="Baron An Evercooren A" first="A." last="Baron-Van Evercooren">A. Baron-Van Evercooren</name><name sortKey="Gumpel, M" sort="Gumpel, M" uniqKey="Gumpel M" first="M." last="Gumpel">M. Gumpel</name><name sortKey="Jeanny, J C" sort="Jeanny, J C" uniqKey="Jeanny J" first="J. C." last="Jeanny">J. C. Jeanny</name><name sortKey="Oliver, L" sort="Oliver, L" uniqKey="Oliver L" first="L." last="Oliver">L. Oliver</name><name sortKey="Raulais, D" sort="Raulais, D" uniqKey="Raulais D" first="D." last="Raulais">D. Raulais</name><name sortKey="Tourbah, A" sort="Tourbah, A" uniqKey="Tourbah A" first="A." last="Tourbah">A. Tourbah</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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